Diablo IV Season of Infernal Chaos officially launches on September 23–24, depending on your time zone. If you want to hit the ground running and maximize your loot, this guide details the best strategies to farm Mythic unique items and Diablo 4 gold in Season 10 (S10).

Best Methods to Farm Mythic Uniques

Season 10 introduces a new guaranteed way to farm Mythic unique items: Mythic Chaos Rifts. However, tried-and-true methods from previous seasons, like Lair bosses and Spark farming, remain highly effective.

1. Lair Bosses

Greater Lair bosses are the traditional method for Mythic farming. Some bosses stand out for their higher drop rates:

· Duriel (King of Maggots)

· Andariel (Maiden of Anguish)

· Harbinger of Death (Vessel of Hatred)

· Belial (Exalted Lair Boss) – Notable for the highest Mythic drop chance and allowing loot selection from other Greater Lair bosses.

Key Tips:

· Access Torment difficulty or higher; these bosses cannot be summoned below this level.

· Collect Lair Boss Keys from Initiate Lair bosses to unlock treasure hoards after defeating each Greater Lair boss.

· Mythic drop rates are low (~2%), so efficient farming with a strong DPS group is recommended.

· Focus on Betrayer’s Husk keys for repeated chest openings, selling unwanted items for gold to buy additional keys.

Key Drops by Boss:

Greater Lair Boss Required Keys Key Drop Location/Boss

Duriel 3x Shard of Agony Grigoire or Varshan

Andariel 3x Pincushioned Doll Lord Zir or The Beast in the Ice

Harbinger of Death 3x Abhorrent Heart Urivar

Belial 2x Betrayer’s Husk Belial’s Ambush

2. Spark Farming

Farming Resplendent Sparks is essential for crafting Mythic Diablo IV items.

Step 1: Create a Seasonal Character

Make a new seasonal character of your main class to transfer gear and builds later. Complete the intro seasonal quest to unlock the S10 Reputation Board.

Step 2: Power-Level to Level 60

  · Option A – Friend Carry: Have a friend run high-tier Pits while you gain experience at the entrance (~20 minutes).

  · Option B – Solo Leveling: Use Whisper Caches, Strongholds, Helltides, and Nightmare Dungeons (~4+ hours).

Step 3: Max the Reputation Board via Infernal Hordes

  · Run Infernal Hordes to farm seasonal reputation, elite enemies, and Resplendent Sparks.

  · Use offerings to increase elite spawns and speed kills.

  · Join other players’ groups via the group finder for faster runs.

Step 4: Claim Sparks & Craft Mythics

  · Two Sparks = one random Mythic Unique.

  · For a specific Mythic, combine Sparks + legendary runes + gold at the Jeweler.

Step 5: Acquire Specific Runes

  · Trade or farm runes via Kurast Undercity and Tribute of Harmony.

  · Exalted Lair bosses are excellent sources for these legendary runes.

3. Mythic Chaos Rifts

Season 10 introduces Mythic Chaos Rifts, the centerpiece for top-tier Mythic farming.

Highlights:

· Guaranteed Mythic Drops: Every Mythic Chaos Rift now guarantees a Mythic item, unlike previous seasons.

· Spawn Locations: Helltides and Nightmare Dungeons.

· Rarity: Focus on Mythic Rifts for the best loot.

Farming Tips:

1. Play on Torment difficulty – required for rift spawns.

2. Prioritize Helltides and Nightmare Dungeons – main spawn areas for Chaos Rifts.

3. Target Mythic Rifts – ensures at least one guaranteed Mythic item.

4. Complete efficiently – these rifts reward valuable loot, experience, and Infernal Warp, which helps level Chaos Perks.

Conclusion

For Diablo IV Season 10, farming Mythic Uniques effectively means combining Lair boss farming, Spark collection, and the new Mythic Chaos Rifts. While Lair bosses and Sparks offer tried-and-true progression, Mythic Chaos Rifts now provide a reliable, guaranteed method to secure the top-tier loot you’ve been chasing.

Maximize efficiency by forming strong groups, targeting specific bosses or rifts, and using Sparks and runes wisely for crafting. With persistence and the right strategies, you can dominate the Season of Infernal Chaos and collect the most coveted Mythic Unique gear in Sanctuary.